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Elevated Human Telomerase Reverse Transcriptase Gene Expression in Blood Cells Associated with Chronic Arsenic Exposure in Inner Mongolia, China

1 Oct 2008

Abstract excerpt

BACKGROUND: Arsenic exposure is associated with human cancer. Telomerase-containing human telomerase reverse transcriptase (hTERT) can extend telomeres of chromosomes, delay senescence, and promote cell proliferation leading to tumorigenesis. OBJECTIVE: The goal of this study was to investigate the effects of As on hTERT mRNA expression in humans and in vitro. METHOD: A total of 324 Inner Mongolia residents who...

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PMID: 19337508
DOI: 10.1289/ehp.11532

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