Article
Genetic polymorphisms in AS3MT and arsenic metabolism in residents of the Red River Delta, Vietnam.
Toxicology and applied pharmacology - 15 Apr 2009
Agusa Tetsuro, Iwata Hisato, Fujihara Junko, Kunito Takashi, Takeshita Haruo, Minh Tu Binh, Trang Pham Thi Kim, Viet Pham Hung, Tanabe Shinsuke
Abstract excerpt
To elucidate the role of genetic factors in arsenic (As) metabolism, we studied associations of single nucleotide polymorphisms (SNPs) in As (+3 oxidation state) methyltransferase (AS3MT) with the As concentrations in hair and urine, and urinary As profile in residents in the Red River Delta, Vietnam. Concentrations of total As in groundwater were 0.7-502 mug/l. Total As levels in groundwater drastically...
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