Article
Overrepresentation of BclI polymorphism of the glucocorticoid receptor gene in pregnant women with HELLP syndrome.
Clinica chimica acta; international journal of clinical chemistry - 1 Jul 2009
Bertalan Rita, Patocs Attila, Nagy Balint, Derzsy Zoltan, Gullai Nora, Szappanos Agnes, Rigo Janos, Racz Karoly
Abstract excerpt
BACKGROUND: Because the pathological background of preeclampsia and its severe variant, HELLP syndrome (hemolysis, elevated liver enzymes and low platelet counts) appears to involve a pathological maternal-fetal immune adaptation, we examined whether any association could exist between these disorders and polymorphisms of the glucocorticoid receptor (GR) gene. METHODS: The BclI, N363S, and ER22/23EK polymorphisms...
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