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Article

Transient in utero disruption of cystic fibrosis transmembrane conductance regulator causes phenotypic changes in alveolar type II cells in adult rats.

BMC cell biology - 31 Mar 2009

Gad Ashraf, Callender Delon L, Killeen Erin, Hudak Joseph, Dlugosz Malgosia A, Larson Janet E, Cohen J Craig, Chander Avinash

Abstract excerpt

BACKGROUND: Mechanicosensory mechanisms regulate cell differentiation during lung organogenesis. We have previously demonstrated that cystic fibrosis transmembrane conductance regulator (CFTR) was integral to stretch-induced growth and development and that transient expression of antisense-CFTR (ASCFTR) had negative effects on lung structure and function. In this study, we examined adult alveolar type II (ATII)...

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Source

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Identifiers

PMID: 19335897
DOI: 10.1186/1471-2121-10-24
PMCID: PMC2675516

Genes

CFTR

Provenance

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