Article
A central role for Foxp3+ regulatory T cells in K-Ras-driven lung tumorigenesis.
PloS one - 1 Jan 2009
Granville Courtney A, Memmott Regan M, Balogh Andria, Mariotti Jacopo, Kawabata Shigeru, Han Wei, Lopiccolo Jaclyn, Foley Jason, Liewehr David J, Steinberg Seth M, Fowler Daniel H, Hollander M Christine, Dennis Phillip A
Abstract excerpt
BACKGROUND: K-Ras mutations are characteristic of human lung adenocarcinomas and occur almost exclusively in smokers. In preclinical models, K-Ras mutations are necessary for tobacco carcinogen-driven lung tumorigenesis and are sufficient to cause lung adenocarcinomas in transgenic mice. Because these mutations confer resistance to commonly used cytotoxic chemotherapies and targeted agents, effective therapies...
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