Article
Impact of a polymorphism in the IL-12p40 gene on the outcome of kidney transplantation.
Transplantation proceedings - 1 Mar 2009
Hoffmann T W, Halimi J-M, Büchler M, Velge-Roussel F, Al-Najjar A, Marliere J-F, Lebranchu Y, Baron C
Abstract excerpt
A number of factors interfere with the outcome of renal transplantation. Revealing genetic factors that impact on graft outcome may have consequences for clinical practice. Interleukin-12 (IL-12), by stimulating interferon gamma (IFNgamma) production, plays a crucial role in immune responses against both graft and viral agents. An A-to-C single nucleotide polymorphism (SNP) within the 3'-untranslated region...
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