Article
Association of TTR polymorphisms with hippocampal atrophy in Alzheimer disease families.
Neurobiology of aging - 1 Feb 2011
Cuenco Karen T, Friedland Robert, Baldwin Clinton T, Guo Jianping, Vardarajan Badri, Lunetta Kathryn L, Cupples L Adrienne, Green Robert C, DeCarli Charles, Farrer Lindsay A
Abstract excerpt
In vitro and animal model studies suggest that transthyretin (TTR) inhibits the production of the amyloid β protein, a major contributor to Alzheimer disease (AD) pathogenesis. We evaluated the association of 16 TTR single nucleotide polymorphisms (SNPs) with AD risk in 158 African American and 469 Caucasian discordant sibships from the MIRAGE Study. There was no evidence for association of TTR with AD in either...
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