Fibroblast growth factor receptor 4 polymorphism is associated with liver cirrhosis in hepatocarcinoma.

doi:10.1371/journal.pone.0122961

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Article

Fibroblast growth factor receptor 4 polymorphism is associated with liver cirrhosis in hepatocarcinoma.

PloS one - 1 Jan 2015

Sheu Ming-Jen, Hsieh Ming-Ju, Chiang Whei-Ling, Yang Shun-Fa, Lee Hsiang-Lin, Lee Liang-Ming, Yeh Chao-Bin

Abstract excerpt

BACKGROUND: Fibroblast growth factor receptor 4 (FGFR4) polymorphisms are positively correlated with tumor progression in numerous malignant tumors. However, the association between FGFR4 genetic variants and the risk of hepatocellular carcinoma (HCC) has not yet been determined. In this study, we investigated the potential associations of FGFR4 single nucleotide polymorphisms (SNPs) with HCC susceptibility and...

Topics

Adult
Aged
Alleles
Asian People
Carcinoma, Hepatocellular
Case-Control Studies
DNA
Female
Genotype
Humans
Liver Cirrhosis
Liver Neoplasms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Male

Middle Aged

Neoplasm Staging

Polymorphism, Single Nucleotide

Real-Time Polymerase Chain Reaction

Receptor, Fibroblast Growth Factor, Type 4

Source

Open in PubMed Open full text

Identifiers

PMID: 25860955
DOI: 10.1371/journal.pone.0122961
PMCID: PMC4393280

Genes

FGFR4
AFP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-25860955-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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