Article
Identification and functional characterization of the promoter of the mouse sodium-activated sodium channel Na(x) gene (Scn7a).
Journal of neuroscience research - 15 Aug 2009
García-Villegas Refugio, López-Alvarez Luz E, Arni Stephan, Rosenbaum Tamara, Morales Marco A
Abstract excerpt
Na(x) is a sodium channel, thought to be a descendant of the voltage-gated sodium channel family. Nevertheless, Na(x) is not activated by voltage but rather by augmentation of extracellular sodium over 150 mM. In the brain, it is localized to the circumventricular organs, important regions for salt and water homeostasis in mammals, where it operates as a sodium-level sensor of body fluid. Na(x) channel is...
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