Article
In silico identification and ex vivo evaluation of Toxoplasma gondii peptides restricted to HLA-A*02, HLA-A*24 and HLA-B*35 alleles in human PBMC from a Colombian population.
Medical microbiology and immunology - 31 Dec 2024
Vargas-Montes Mónica, Valencia-Jaramillo María Camila, Valencia-Hernández Juan David, Gómez-Marín Jorge Enrique, Arenas Ailan Farid, Cardona Néstor
Abstract excerpt
Toxoplasma gondii infects approximately 30% of the population, and there is currently no approved vaccine. Identifying immunogenic peptides with high affinity to different HLA molecules is a promising vaccine strategy. This study used an in silico approach using artificial neural networks to identify T. gondii peptides restricted to HLA-A*02, HLA-A*24, and HLA-B*35 alleles. Proteomes from seven T. gondii strains...
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