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Article

Involvement of NF- B and AP-1 in COX-2 upregulation by human papillomavirus 16 E5 oncoprotein

25 Mar 2009

Abstract excerpt

The human papillomavirus (HPV) E6 and E7 oncoproteins play important roles in cervical carcinogenesis through multiple mechanisms, including upregulation of cyclooxygenase-2 (COX-2), which has been shown to be involved in both carcinogenesis and cancer progression. To explore the role of E5 in cervical carcinogenesis, we herein investigated the effect of HPV 16 E5 on COX-2 expression. Our results revealed that E5...

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PMID: 19321801
DOI: 10.1093/carcin/bgp066

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Involvement of NF- B and AP-1 in COX-2 upregulation by human papillomavirus 16 E5 oncoproteinPMID 19321801Read ↗

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The HPV-16 E5 protein represses expression of stress pathway genes XBP-1 and COX-2 in genital keratinocytes.Semantic proximity Read ↗

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