Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Involvement of the interaction between p21 and proliferating cell nuclear antigen for the maintenance of G2/M arrest after DNA damage.

The Journal of biological chemistry - 16 Nov 2001

Ando T, Kawabe T, Ohara H, Ducommun B, Itoh M, Okamoto T

Abstract excerpt

Although a major effect of p21, a cyclin-dependent kinase inhibitor, is considered to be exerted during G(1) phase of the cell cycle, p21 gene knock-out studies suggested its involvement in G(2)/M checkpoint as well. Here we demonstrate evidence that p21 is required for the cell cycle arrest at G...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Binding, Competitive
Share to Cisplatin
Share to Cyclin-Dependent Kinase Inhibitor p21

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cyclins

Share to G2 Phase

Share to Mitosis

Share to Precipitin Tests

Share to Proliferating Cell Nuclear Antigen

Source

Identifiers

PMID: 11559705
DOI: 10.1074/jbc.M106460200

Genes

PCNA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-11559705-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Involvement of the interaction between p21 and proliferating cell nuclear antigen for the maintenance of G2/M arrest after DNA damage.PMID 11559705Read ↗

Enhanced sensitivity to cis-diamminedichloroplatinum(II) of a human carcinoma cell line with mutated p53 gene by cyclin-dependent kinase inhibitor p21(WAF1) expression.Semantic proximity Read ↗

The Cyclin-Dependent Kinase Inhibitor p21CDKN1A as a Target of Anti-Cancer DrugsSemantic proximity Read ↗

Upregulation of p27 and its inhibition of CDK2/cyclin E activity following DNA damage by a novel platinum agent are dependent on the expression of p21Semantic proximity Read ↗

Requirement for p53 and p21 to sustain G2 arrest after DNA damage.Semantic proximity Read ↗

Degradation of p21CDKN1A after DNA damage is independent of type of lesion, and is not required for DNA repair.Semantic proximity Read ↗

Mitotic p21Cip1/CDKN1A is regulated by cyclin-dependent kinase 1 phosphorylation.Semantic proximity Read ↗

p53-mediated G1 arrest requires the induction of both p21 and Killin in human colon cancer cellsSemantic proximity Read ↗

Role of p53 and p21waf1/cip1 in senescence-like terminal proliferation arrest induced in human tumor cells by chemotherapeutic drugsSemantic proximity Read ↗

Cell cycle expression and p53 regulation of the cyclin-dependent kinase inhibitor p21.Semantic proximity Read ↗

Phosphorylation of p21 in G2/M promotes cyclin B-Cdc2 kinase activity.Semantic proximity Read ↗

p21(WAF1/CIP1) inhibits cell cycle progression but not G2/M-phase transition following methylmercury exposure.Semantic proximity Read ↗

Diallyl disulfide induces reversible G2/M phase arrest on a p53-independent mechanism in human colon cancer HCT-116 cellsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.