Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Pharmacogenetics of low dose clonidine in irritable bowel syndrome.

Neurogastroenterology and motility - 1 Apr 2009

Camilleri M, Busciglio I, Carlson P, McKinzie S, Burton D, Baxter K, Ryks M, Zinsmeister A R

Abstract excerpt

Adrenergic and serotonergic (ADR-SER) mechanisms alter gut (gastrointestinal, GI) sensorimotor functions. We aimed to determine whether candidate ADR-SER genes affect GI responses to low dose clonidine (CLO) in humans. Forty healthy and 120 irritable bowel syndrome (IBS) participants received CLO, 0.1 mg or 0.15 mg b.i.d., for 6 days. At baseline and post-CLO, we measured: gastric volume (GV); satiation volume;...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adrenergic alpha-Agonists
Share to Dose-Response Relationship, Drug

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Heterotrimeric GTP-Binding Proteins

Share to Irritable Bowel Syndrome

Share to Pharmacogenetics

Share to Polymorphism, Single Nucleotide

Share to Receptors, Adrenergic, alpha-2

Share to Serotonin Plasma Membrane Transport Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 19309415
DOI: 10.1111/j.1365-2982.2009.01263.x
PMCID: PMC2690641

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Pharmacogenetics of low dose clonidine in irritable bowel syndrome.PMID 19309415Read ↗

Candidate genes and sensory functions in health and irritable bowel syndrome.Semantic proximity Read ↗

An exploratory study of the association of adrenergic and serotonergic genotype and gastrointestinal motor functions.Semantic proximity Read ↗

Association of the 1438G/A and 102T/C Polymorphism of the 5-HT2A Receptor Gene With Irritable Bowel Syndrome 5-HT2A Gene Polymorphism in Irritable Bowel SyndromeSemantic proximity Read ↗

Genetics of human gastrointestinal sensation.Semantic proximity Read ↗

Association of distinct alpha(2) adrenoceptor and serotonin transporter polymorphisms with constipation and somatic symptoms in functional gastrointestinal disorders.Semantic proximity Read ↗

Genetic variation in endocannabinoid metabolism, gastrointestinal motility, and sensation.Semantic proximity Read ↗

Cannabinoid receptor 1 gene and irritable bowel syndrome: phenotype and quantitative traits.Semantic proximity Read ↗

Genetic variation in the beta-2 adrenergic receptor (ADRB2) predicts functional gastrointestinal diagnoses and poorer health-related quality of life.Semantic proximity Read ↗

Pharmacogenetic trial of a cannabinoid agonist shows reduced fasting colonic motility in patients with nonconstipated irritable bowel syndrome.Semantic proximity Read ↗

Relationship of cytochrome P450 pharmacogenetics to the effects of yohimbine on gastrointestinal transit and catecholamines in healthy subjects.Semantic proximity Read ↗

Catecholaminergic Gene Polymorphisms Are Associated with GI Symptoms and Morphological Brain Changes in Irritable Bowel Syndrome.Semantic proximity Read ↗

Domperidone treatment for gastroparesis: demographic and pharmacogenetic characterization of clinical efficacy and side-effects.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.