Article
Defining the impact of Getah virus envelope protein glycosylation site mutations on viral replication, host adaptation, virulence, and immune evasion.
PLoS pathogens - 1 Apr 2026
Ren Tongwei, Liu Muyang, Li Peijie, Zhang Liping, Zhong Zhen, Zhou Lingshan, Qin Yifeng, Ouyang Kang, Yin Yeshi, Chen Ying, Huang Weijian, Wei Zuzhang
Abstract excerpt
The N-linked glycosylation of alphavirus envelope proteins plays critical roles in glycoprotein folding, host-receptor interactions, immune evasion, and pathogenicity. Getah virus (GETV) has two putative N-linked glycosylation sites (N-200 and N-262) in the E2 and one (N-141) in E1. We generated seven glycosylation-deficient mutants and evaluated their fitness across mammalian cells, mosquitoes, and mouse models....
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