Irinotecan toxicity: genes or intestinal microflora?

Abstract excerpt

As research advances, a growing body of evidence shows that the individual response to any drug, i.e. effectiveness and toxicity, may be influenced by genetic polymorphisms. In the case of anticancer chemotherapeutic agents, characterised by a low therapeutic index, pharmacogenomic studies could stratify patients for expected response and adverse effects, potentially allowing more rational prescriptions.

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