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Article

Pharmacogenetics of irinotecan toxicity

1 Oct 2004

Abstract excerpt

Irinotecan is an anticancer drug approved in combination therapy for advanced colorectal cancer. Severe, life-threatening toxicities can occur from irinotecan treatment. Although multiple genes may play a role in irinotecan activity, the UDP glycuronosyltransferase 1 family, polypeptide A1 (UGT1A1) enzyme has been strongly associated with toxicity. A common dinucleotide repeat polymorphism in the UGT1A1 promoter...

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PMID: 15469406
DOI: 10.1517/14622416.5.7.835

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