Article
Antioxidant effect of haptoglobin phenotypes against DNA damage induced by hydrogen peroxide in human leukocytes.
Genetics and molecular research : GMR - 1 Jan 2009
Moreira L R S, Miranda-Vilela A L, Silva I C R, Akimoto A K, Klautau-Guimarães M N, Grisolia C K
Abstract excerpt
Human haptoglobin is classified into three major phenotypes: Hp1-1, Hp2-1 and Hp2-2; there are two autosomal alleles Hp*1 and Hp*2, and the Hp*1 allele has two subtypes, Hp*1F and Hp*1S. Haptoglobin acts as an antioxidant, preventing hemoglobin-driven oxidative damage. We used the comet assay to examine oxidative damage to DNA induced by hydrogen peroxide in human leukocytes; we also looked for differences in the...
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