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Identification of diterpenoid compounds that interfere with Fli-1 DNA binding to suppress leukemogenesis

11 Feb 2019

Abstract excerpt

The ETS transcription factor Fli-1 controls the expression of genes involved in hematopoiesis including cell proliferation, survival, and differentiation. Dysregulation of Fli-1 induces hematopoietic and solid tumors, rendering it an important target for therapeutic intervention. Through high content screens of a library of chemicals isolated from medicinal plants in China for inhibitors of a Fli-1...

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PMID: 30741932
DOI: 10.1038/s41419-019-1363-1

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