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Article

NPM-ALK inhibits the p53 tumor suppressor pathway in an MDM2 and JNK-dependent manner

13 Mar 2009

Abstract excerpt

Anaplastic large cell lymphoma (ALCL) is characterized by the presence of the t(2;5)(p23;q35) generating the nucleophosmin-anaplastic lymphoma kinase (NPM-ALK) fusion protein, a hyperactive kinase with transforming properties. Among these properties is the ability to regulate activity of the p53 tumor suppressor protein. In many human cancers, p53 is inactivated by mutation or other means, in some cases as a...

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PMID: 19286999
DOI: 10.1182/blood-2008-06-160168

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