Article
Role of bound Zn(II) in the CadC Cd(II)/Pb(II)/Zn(II)-responsive repressor.
The Journal of biological chemistry - 29 May 2009
Kandegedara Ashoka, Thiyagarajan Saravanamuthu, Kondapalli Kalyan C, Stemmler Timothy L, Rosen Barry P
Abstract excerpt
The Staphylococcus aureus plasmid pI258 cadCA operon encodes a P-type ATPase, CadA, that confers resistance to Cd(II)/Pb(II)/Zn(II). Expression is regulated by CadC, a homodimeric repressor that dissociates from the cad operator/promoter upon binding of Cd(II), Pb(II), or Zn(II). CadC is a member of the ArsR/SmtB family of metalloregulatory proteins. The crystal structure of CadC shows two types of metal binding...
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