Graded expression of zinc-responsive genes through two regulatory zinc-binding sites in Zur.

Abstract excerpt

Zinc is one of the essential transition metals in cells. Excess or lack of zinc is detrimental, and cells exploit highly sensitive zinc-binding regulators to achieve homeostasis. In this article, we present a crystal structure of active Zur from Streptomyces coelicolor with three zinc-binding sites (C-, M-, and D-sites). Mutations of the three sites differentially affected sporulation and transcription of target...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Binding Sites
• Share to Gene Expression Regulation, Bacterial