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Article

Characterizing the developmental pathways TTF-1 , NKX2–8 , and PAX9 in lung cancer

11 Mar 2009

Abstract excerpt

We investigated the clinical implications of lung developmental transcription factors (TTF-1, NKX2-8, and PAX9) that we recently discovered as cooperating oncogenes activated by way of gene amplification at chromosome 14q13 in lung cancer. Using stable transfectants of human bronchial epithelial cells, RNA expression profiles (signatures) representing activation of the biological pathways defined by each of the 3...

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PMID: 19279207
DOI: 10.1073/pnas.0900827106

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