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Article

Role of Helicobacter pylori CagA molecular variations in induction of host phenotypes with carcinogenic potential.

The Journal of infectious diseases - 15 Apr 2009

Schneider Natasha, Krishna Uma, Romero-Gallo Judith, Israel Dawn A, Piazuelo M Blanca, Camargo M Constanza, Sicinschi Liviu A, Schneider Barbara G, Correa Pelayo, Peek Richard M

Abstract excerpt

Helicobacter pylori cagA-positive strains exert population-specific risks for gastric cancer. We determined whether variations in CagA phosphorylation motifs were associated with carcinogenic or proinflammatory epithelial phenotypes induced by strains from regions with divergent cancer risks (Colombia and Nashville, TN). Motif number was significantly related to levels of CagA phosphorylation and cytoskeletal...

Topics

Amino Acid Motifs
Antigens, Bacterial
Bacterial Proteins
Carcinoma
Cell Line
Colombia
Female
Helicobacter Infections
Helicobacter pylori
Host-Pathogen Interactions

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Humans

Male

Phenotype

Phosphorylation

Protein Isoforms

Risk Factors

Stomach Neoplasms

Tennessee

Source

Open in PubMed Open full text

Identifiers

PMID: 19278338
DOI: 10.1086/597416
PMCID: PMC2828761

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-19278338-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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