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Analysis of <i>cagA</i> in <i>Helicobacter pylori</i> Strains from Colombian Populations with Contrasting Gastric Cancer Risk Reveals a Biomarker for Disease Severity

1 Oct 2011

Abstract excerpt

BACKGROUND: Helicobacter pylori infection is a risk factor for the development of gastric cancer, and the bacterial oncoprotein CagA contributes to gastric carcinogenesis. METHODS: We analyzed H. pylori isolates from persons in Colombia and observed that there was marked variation among strains in levels of CagA expression. To elucidate the basis for this variation, we analyzed sequences upstream from the CagA...

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PMID: 21859954
DOI: 10.1158/1055-9965.epi-11-0548

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