Article
Novel strategies to mine alcoholism-related haplotypes and genes by combining existing knowledge framework.
Science in China. Series C, Life sciences - 1 Feb 2009
Zhang RuiJie, Li Xia, Jiang YongShuai, Liu GuiYou, Li ChuanXing, Zhang Fan, Xiao Yun, Gong BinSheng
Abstract excerpt
High-throughout single nucleotide polymorphism detection technology and the existing knowledge provide strong support for mining the disease-related haplotypes and genes. In this study, first, we apply four kinds of haplotype identification methods (Confidence Intervals, Four Gamete Tests, Solid Spine of LD and fusing method of haplotype block) into high-throughout SNP genotype data to identify blocks, then use...
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