Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Plasma angiotensin-converting enzyme in Alzheimer's disease.

Journal of Alzheimer's disease : JAD - 1 Jan 2009

Vardy Emma R L C, Rice Penny J, Bowie Peter C W, Holmes John D, Catto Andrew J, Hooper Nigel M

Abstract excerpt

The insertion allele in the gene encoding angiotensin-converting enzyme (ACE) is a risk factor for Alzheimer's disease (AD) and ACE is one of several peptidases that have the ability to degrade the neurotoxic amyloid-beta peptide. ACE is a membrane-bound peptidase that is also present in a soluble form in plasma as a result of a zinc metalloprotease-mediated shedding event. Here we aimed to determine whether...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Age of Onset
Share to Alzheimer Disease
Share to Apolipoprotein E4

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genetic Linkage

Share to Metalloproteases

Share to Peptidyl-Dipeptidase A

Share to ROC Curve

Source

Identifiers

PMID: 19276555
DOI: 10.3233/JAD-2009-1002

Genes

ACE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Plasma angiotensin-converting enzyme in Alzheimer's disease.PMID 19276555Read ↗

Angiotensin converting enzyme gene polymorphism in Alzheimer's disease.Semantic proximity Read ↗

Effect of ACE mutations on blood ACE phenotype parameters.Semantic proximity Read ↗

Amyloid beta-protein is degraded by cellular angiotensin-converting enzyme (ACE) and elevated by an ACE inhibitor.Semantic proximity Read ↗

Angiotensin converting enzyme and endothelial nitric oxide synthase DNA polymorphisms and late onset Alzheimer's disease.Semantic proximity Read ↗

Soluble adhesion molecules and angiotensin-converting enzyme in dementia.Semantic proximity Read ↗

Plasma renin-angiotensin system-regulating aminopeptidase activities are modified in early stage Alzheimer's disease and show gender differences but are not related to apolipoprotein E genotype.Semantic proximity Read ↗

The angiotensin-converting enzyme gene as a possible risk or protective factor in Alzheimer's disease.Semantic proximity Read ↗

Angiotensin-converting enzyme degrades Alzheimer amyloid beta-peptide (A beta ); retards A beta aggregation, deposition, fibril formation; and inhibits cytotoxicity.Semantic proximity Read ↗

An angiotensin I-converting enzyme mutation (Y465D) causes a dramatic increase in blood ACE via accelerated ACE shedding.Semantic proximity Read ↗

Catabolic attacks of membrane-bound angiotensin-converting enzyme on the N-terminal part of species-specific amyloid-beta peptides.Semantic proximity Read ↗

Kinetic and structural characterization of amyloid-β peptide hydrolysis by human angiotensin-1-converting enzyme.Semantic proximity Read ↗

Increased plasma levels of matrix metalloproteinase-9 in patients with Alzheimer's disease.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.