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Article

Genetic variation in ANGPTL4 provides insights into protein processing and function.

The Journal of biological chemistry - 8 May 2009

Yin Wu, Romeo Stefano, Chang Shurong, Grishin Nick V, Hobbs Helen H, Cohen Jonathan C

Abstract excerpt

Angiopoietin-like protein 4 (ANGPTL4) is a secreted protein that modulates the disposition of circulating triglycerides (TG) by inhibiting lipoprotein lipase (LPL). Here we examine the steps involved in the synthesis and post-translational processing of ANGPTL4, and the effects of a naturally occurring sequence variant (E40K) that is associated with lower plasma TG levels in humans. Expression of the wild-type...

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Share to Angiopoietins
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hypertriglyceridemia

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Share to Protein Processing, Post-Translational

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Source

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Identifiers

PMID: 19270337
DOI: 10.1074/jbc.M900553200
PMCID: PMC2676053

Genes

ANGPTL4
LPL

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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