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Article

Protein region important for regulation of lipid metabolism in angiopoietin-like 3 (ANGPTL3): ANGPTL3 is cleaved and activated in vivo.

The Journal of biological chemistry - 24 Oct 2003

Ono Mitsuru, Shimizugawa Tetsuya, Shimamura Mitsuru, Yoshida Kenichi, Noji-Sakikawa Chisa, Ando Yosuke, Koishi Ryuta, Furukawa Hidehiko

Abstract excerpt

Angiopoietin-like 3 (ANGPTL3) is a secreted protein that is mainly expressed in the liver and regulates lipid metabolism by inhibiting the lipolysis of triglyceriderich lipoproteins. Using deletion mutants of human ANGPTL3, we demonstrated that the N-terminal coiled-coil domain-containing fragmen...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 12909640
DOI: 10.1074/jbc.M302861200

Genes

ANGPTL3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-12909640-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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