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Article

Genome-wide association and replication studies identified TRHR as an important gene for lean body mass.

American journal of human genetics - 1 Mar 2009

Liu Xiao-Gang, Tan Li-Jun, Lei Shu-Feng, Liu Yong-Jun, Shen Hui, Wang Liang, Yan Han, Guo Yan-Fang, Xiong Dong-Hai, Chen Xiang-Ding, Pan Feng, Yang Tie-Lin, Zhang Yin-Ping, Guo Yan, Tang Nelson L, Zhu Xue-Zhen, Deng Hong-Yi, Levy Shawn, Recker Robert R, Papasian Christopher J, Deng Hong-Wen

Abstract excerpt

Low lean body mass (LBM) is related to a series of health problems, such as osteoporotic fracture and sarcopenia. Here we report a genome-wide association (GWA) study on LBM variation, by using Affymetrix 500K single-nucleotide polymorphism (SNP) arrays. In the GWA scan, we tested 379,319 eligible SNPs in 1,000 unrelated US whites and found that two SNPs, rs16892496 (p = 7.55 x 10(-8)) and rs7832552 (p = 7.58 x...

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Source

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Identifiers

PMID: 19268274
DOI: 10.1016/j.ajhg.2009.02.004
PMCID: PMC2668008

Genes

TRHR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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