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Mechanism of 5-aminolevulinate synthase and the role of the protein environment in controlling the cofactor chemistry.

Cellular and molecular biology (Noisy-le-Grand, France) - 1 Dec 2002

Ferreira G C, Zhang J S

Abstract excerpt

5-Aminolevulinate synthase, a pyridoxal 5'-phosphate-dependent enzyme of the alpha-oxoamine synthase family, catalyzes the first step of the heme biosynthetic pathway in mammalian cells. This reaction entails the condensation of glycine with succinyl-coenzyme A to yield 5-aminolevulinate, carbon dioxide and CoA. Mutations in the erythroid aminolevulinate synthase gene lead to a defective enzyme and are associated...

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PMID: 12699240

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

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