Article
Hammondia hammondi, an avirulent relative of Toxoplasma gondii, has functional orthologs of known T. gondii virulence genes.
Proceedings of the National Academy of Sciences of the United States of America - 30 Apr 2013
Walzer Katelyn A, Adomako-Ankomah Yaw, Dam Rachel A, Herrmann Daland C, Schares Gereon, Dubey Jitender P, Boyle Jon P
Abstract excerpt
Toxoplasma gondii is a ubiquitous protozoan parasite capable of infecting all warm-blooded animals, including humans. Its closest extant relative, Hammondia hammondi, has never been found to infect humans and, in contrast to T. gondii, is highly attenuated in mice. To better understand the genetic bases for these phenotypic differences, we sequenced the genome of a H. hammondi isolate (HhCatGer041) and found the...
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