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Article

Extremely high mutation rate of a hammerhead viroid.

Science (New York, N.Y.) - 6 Mar 2009

Gago Selma, Elena Santiago F, Flores Ricardo, Sanjuán Rafael

Abstract excerpt

The mutation rates of viroids, plant pathogens with minimal non-protein-coding RNA genomes, are unknown. Their replication is mediated by host RNA polymerases and, in some cases, by hammerhead ribozymes, small self-cleaving motifs embedded in the viroid. By using the principle that the population frequency of nonviable genotypes equals the mutation rate, we screened for changes that inactivated the hammerheads of...

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Identifiers

PMID: 19265013
DOI: 10.1126/science.1169202

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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