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Article

A constant rate of spontaneous mutation in DNA-based microbes.

Proceedings of the National Academy of Sciences of the United States of America - 15 Aug 1991

Drake J W

Abstract excerpt

In terms of evolution and fitness, the most significant spontaneous mutation rate is likely to be that for the entire genome (or its nonfrivolous fraction). Information is now available to calculate this rate for several DNA-based haploid microbes, including bacteriophages with single- or double-stranded DNA, a bacterium, a yeast, and a filamentous fungus. Their genome sizes vary by approximately 6500-fold. Their...

Topics

Bacteriophage lambda
Base Composition
Biological Evolution
Coliphages
DNA, Bacterial
DNA, Fungal
DNA, Viral
Escherichia coli
Genes, Bacterial
Genes, Fungal
Genes, Viral

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutation

Neurospora crassa

Saccharomyces cerevisiae

Species Specificity

T-Phages

Source

Open in PubMed Open full text

Identifiers

PMID: 1831267
DOI: 10.1073/pnas.88.16.7160
PMCID: PMC52253

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1831267-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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