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Activities of ICP0 Involved in the Reversal of Silencing of Quiescent Herpes Simplex Virus 1

17 Mar 2011

Abstract excerpt

ICP0 is a transcriptional activating protein required for the efficient replication and reactivation of latent herpes simplex virus 1 (HSV-1). Multiple regions of ICP0 contribute its activity, the most prominent of which appears to be the RING finger, which confers E3 ubiquitin ligase activity. A region in the C terminus of ICP0 has also been implicated in several activities, including the disruption of a...

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PMID: 21411540
DOI: 10.1128/jvi.02265-10

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Activities of ICP0 Involved in the Reversal of Silencing of Quiescent Herpes Simplex Virus 1PMID 21411540Read ↗

Reversal of Heterochromatic Silencing of Quiescent Herpes Simplex Virus Type 1 by ICP0Semantic proximity Read ↗

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Herpes simplex virus-infected cell protein 0 blocks the silencing of viral DNA by dissociating histone deacetylases from the CoREST-REST complex.Semantic proximity Read ↗

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ICP0 enables and monitors the function of D cyclins in herpes simplex virus 1 infected cells.Semantic proximity Read ↗

The Replication Defect of ICP0-Null Mutant Herpes Simplex Virus 1 Can Be Largely Complemented by the Combined Activities of Human Cytomegalovirus Proteins IE1 and pp71Semantic proximity Read ↗

Replication of ICP0-null mutant herpes simplex virus type 1 is restricted by both PML and Sp100.Semantic proximity Read ↗

Herpesviral ICP0 Protein Promotes Two Waves of Heterochromatin Removal on an Early Viral Promoter during Lytic InfectionSemantic proximity Read ↗

The Herpes Simplex Virus ICP0 RING Finger Domain Inhibits IRF3- and IRF7-Mediated Activation of Interferon-Stimulated GenesSemantic proximity Read ↗

Functional Interaction between Class II Histone Deacetylases and ICP0 of Herpes Simplex Virus Type 1Semantic proximity Read ↗

During its nuclear phase the multifunctional regulatory protein ICP0 undergoes proteolytic cleavage characteristic of polyproteins.Semantic proximity Read ↗

The CoREST/REST Repressor Is both Necessary and Inimical for Expression of Herpes Simplex Virus GenesSemantic proximity Read ↗

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