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Article

ICP0 enables and monitors the function of D cyclins in herpes simplex virus 1 infected cells.

Proceedings of the National Academy of Sciences of the United States of America - 25 Aug 2009

Kalamvoki Maria, Roizman Bernard

Abstract excerpt

The herpes simplex virus 1 ICP0 is a regulatory protein. Early in infection ICP0 localizes in ND10 bodies and performs two functions: As an E3 ligase in conjunction with E2 UbcH5a conjugating enzyme, it degrades the ND10 components PML and SP100. Concurrently, it suppresses the silencing of viral DNA by dispersing the HDAC1/CoREST/REST/LSD1 repressor complex. Subsequently, ICP0 is exported to the cytoplasm. In...

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Source

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Identifiers

PMID: 19706544
DOI: 10.1073/pnas.0906905106
PMCID: PMC2732861

Genes

HDAC1
PML
REST

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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ICP0 enables and monitors the function of D cyclins in herpes simplex virus 1 infected cells.PMID 19706544Read ↗

During its nuclear phase the multifunctional regulatory protein ICP0 undergoes proteolytic cleavage characteristic of polyproteins.Semantic proximity Read ↗

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Herpesviral ICP0 Protein Promotes Two Waves of Heterochromatin Removal on an Early Viral Promoter during Lytic InfectionSemantic proximity Read ↗

ICP0 induces the accumulation of colocalizing conjugated ubiquitin.Semantic proximity Read ↗

Characterization of Elements Regulating the Nuclear-to-Cytoplasmic Translocation of ICP0 in Late Herpes Simplex Virus 1 Infection.Semantic proximity Read ↗

Replication of ICP0-null mutant herpes simplex virus type 1 is restricted by both PML and Sp100.Semantic proximity Read ↗

Alphaherpesvirus Proteins Related to Herpes Simplex Virus Type 1 ICP0 Affect Cellular Structures and ProteinsSemantic proximity Read ↗

Functional Interaction between Class II Histone Deacetylases and ICP0 of Herpes Simplex Virus Type 1Semantic proximity Read ↗

Components of Promyelocytic Leukemia Nuclear Bodies (ND10) Act Cooperatively To Repress Herpesvirus InfectionSemantic proximity Read ↗

Role of ND10 nuclear bodies in the chromatin repression of HSV-1Semantic proximity Read ↗

Herpes simplex virus-infected cell protein 0 blocks the silencing of viral DNA by dissociating histone deacetylases from the CoREST-REST complex.Semantic proximity Read ↗

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