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EBV Lytic-Phase Protein BGLF5 Contributes to TLR9 Downregulation during Productive Infection

30 Dec 2010

Abstract excerpt

Viruses use a wide range of strategies to modulate the host immune response. The human gammaherpesvirus EBV, causative agent of infectious mononucleosis and several malignant tumors, encodes proteins that subvert immune responses, notably those mediated by T cells. Less is known about EBV interference with innate immunity, more specifically at the level of TLR-mediated pathogen recognition. The viral dsDNA sensor...

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PMID: 21191071
DOI: 10.4049/jimmunol.0903120

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