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Article

BMP15 mutations associated with primary ovarian insufficiency cause a defective production of bioactive protein.

Human mutation - 1 May 2009

Rossetti Raffaella, Di Pasquale Elisa, Marozzi Anna, Bione Silvia, Toniolo Daniela, Grammatico Paola, Nelson Lawrence M, Beck-Peccoz Paolo, Persani Luca

Abstract excerpt

Bone morphogenetic protein-15 (BMP15) is selectively synthesized by oocytes as a pre-proprotein and is considered an ovarian follicle organizer whose adequate function is critical for female fertility. Missense mutations were reported in primary ovarian insufficiency (POI) but their biological impact remained unexplored. Here, screening of 300 unrelated idiopathic overt POI women with primary or secondary...

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Source

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Identifiers

PMID: 19263482
DOI: 10.1002/humu.20961
PMCID: PMC2677132

Genes

BMP15

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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