Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Global downstream BMP15 pathway analysis in human ovarian granulosa cells reveals novel genetic variations associated with primary ovarian insufficiency.

Maturitas - 1 Oct 2026

Rossetti Raffaella, Fornili Marco, Moleri Silvia, Ferrari Ilaria, Gentilini Davide, Carbone Erika, Paffoni Alessio, Somigliana Edgardo, Biganzoli Elia, Marozzi Anna, Brancati Francesco, Moretti Costanzo, Giuliani Cristina, Persani Luca

Abstract excerpt

OBJECTIVES: Primary ovarian insufficiency (POI) is a fertility disorder with a well-established genetic component, but many cases still remain idiopathic. Approximately 1.5-12% of patients with POI can carry a variant in the BMP15 gene, depending on the population and the diagnostic criteria. We hypothesize that genetic variations within pathways downstream of BMP15 activity in ovarian granulosa cells (GCs) may...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Ovarian function and disorders
Share to Reproductive Biology and Fertility

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to TGF-β signaling in diseases

Source

Identifiers

PMID: 42664615
DOI: 10.1016/j.maturitas.2026.109093

Genes

BMP15
ID1
SAMD11
SMAD6
USP35

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 26 Oct 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Global downstream BMP15 pathway analysis in human ovarian granulosa cells reveals novel genetic variations associated with primary ovarian insufficiency.PMID 42664615Read ↗

BMP15 Mutations Associated With Primary Ovarian Insufficiency Reduce Expression, Activity, or Synergy With GDF9.Semantic proximity Read ↗

Novel bone morphogenetic protein 15 (BMP15) gene variants implicated in premature ovarian insufficiency.Semantic proximity Read ↗

BMP15 c.-9C>G promoter sequence variant may contribute to the cause of non-syndromic premature ovarian failure.Semantic proximity Read ↗

BMP15 mutations associated with primary ovarian insufficiency cause a defective production of bioactive protein.Semantic proximity Read ↗

Fundamental role of BMP15 in human ovarian folliculogenesis revealed by null and missense mutations associated with primary ovarian insufficiency.Semantic proximity Read ↗

The fundamental role of bone morphogenetic protein 15 in ovarian function and its involvement in female fertility disordersSemantic proximity Read ↗

Implication of novel BMP15 and GDF9 variants in unexpected poor ovarian responseSemantic proximity Read ↗

Hypergonadotropic ovarian failure associated with an inherited mutation of human bone morphogenetic protein-15 (BMP15) gene.Semantic proximity Read ↗

Variants of the BMP15 gene in a cohort of patients with premature ovarian failure.Semantic proximity Read ↗

Molecular Aspects and Clinical Relevance of GDF9 and BMP15 in Ovarian Function.Semantic proximity Read ↗

Characterization of a novel mutation V136L in bone morphogenetic protein 15 identified in a woman affected by POI.Semantic proximity Read ↗

Characterization of a Novel Mutation V136L in Bone Morphogenetic Protein 15 Identified in a Woman Affected by POI.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.