Risk to the breast-fed neonate from codeine treatment to the mother: a quantitative mechanistic modeling study.

Abstract excerpt

Administering codeine to breast-feeding mothers had been considered safe until the recent death of a breast-fed neonate whose mother had been prescribed codeine. We investigated the risk of opioid poisoning to breast-fed neonates using coupled physiologically based pharmacokinetic models for the mother and child. Neonatal morphine plasma concentrations were simulated for various combinations of cytochrome P450...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Administration, Oral
• Share to Analgesics, Opioid