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Article

Bestrophin-1 influences transepithelial electrical properties and Ca2+ signaling in human retinal pigment epithelium.

Molecular vision - 1 Jan 2015

Marmorstein Alan D, Kinnick Tyson R, Stanton J Brett, Johnson Adiv A, Lynch Ronald M, Marmorstein Lihua Y

Abstract excerpt

PURPOSE: Mutations in BEST1, encoding Bestrophin-1 (Best1), cause Best vitelliform macular dystrophy (BVMD) and other inherited retinal degenerative diseases. Best1 is an integral membrane protein localized to the basolateral plasma membrane of the retinal pigment epithelium (RPE). Data from numerous in vitro and in vivo models have demonstrated that Best1 regulates intracellular Ca2+ levels. Although it is known...

Topics

Adenosine Triphosphate
Adenoviruses, Human
Bestrophins
Calcium
Calcium Signaling
Cell Membrane
Chloride Channels
Epithelial Cells
Eye Proteins
Fetus
Gene Expression

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Genetic Vectors

HEK293 Cells

Humans

Ion Transport

Ionomycin

Membrane Potentials

Mutation

Source

Open in PubMed Open full text

Identifiers

PMID: 25878489
PMCID: PMC4390793

Genes

RPE
BEST1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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Bestrophin-1 influences transepithelial electrical properties and Ca2+ signaling in human retinal pigment epithelium.PMID 25878489Read ↗

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