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Article

Directed differentiation of mouse cochlear neural progenitors in vitro.

American journal of physiology. Cell physiology - 1 Mar 2009

Lin Jizhen, Feng Ling, Hamajima Yuki, Komori Masahiro, Burns Terry C, Fukudome Shinji, Anderson John, Wang Dong, Verfaillie Catherine M, Low Walter C

Abstract excerpt

Multipotent cochlear neural progenitors (CNPs) in the organ of Corti hold the promise for cell replacement in degenerative hearing disorders. However, not much is known about the CNPs and the specific conditions for their differentiation. Here we isolate the CNPs from the postnatal day 1 organ of Corti in mice and demonstrate their capability to self-renew and to differentiate into hair cell-like and neuronal...

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Identifiers

PMID: 19261910
DOI: 10.1152/ajpcell.00324.2008
PMCID: PMC2660259

Genes

BDNF
EGF
SHH

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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