Article
Widespread mismatch repair protein expression in canine cutaneous mast cell tumors.
Veterinary pathology - 1 Mar 2009
Munday J S, French A F, Gibson I R, Gwynne K
Abstract excerpt
Cutaneous mast cell tumors (MCTs) are common canine neoplasms. Some dog breeds more frequently develop MCTs, suggesting a genetically mediated predisposition. In humans, the most common inherited cancer predisposition is caused by germline defects in the mismatch repair (MMR) genes. To investigate whether inherited defects in the MMR genes predispose some dogs to MCT development, MMR expression in 22 MCTs from...
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