Article
Developing a quantitative measure of alcohol consumption for genomic studies on prospective cohorts.
Journal of studies on alcohol and drugs - 1 Mar 2009
Agrawal Arpana, Grant Julia D, Littlefield Andrew, Waldron Mary, Pergadia Michele L, Lynskey Michael T, Madden Pamela A F, Todorov Alexandre, Trull Timothy, Bucholz Kathleen K, Todd Richard D, Sher Kenneth, Heath Andrew C
Abstract excerpt
OBJECTIVE: The purpose of this study was to develop a quantitative measure of alcohol consumption for gene-mapping studies. METHOD: Using a sample of 3,787 young-adult twin women and an independent sample of 489 men and women from a college drinking study, we developed an alcohol-consumption factor score indexed by (1) maximum typical consumption (log-transformed quantity frequency [LQNTFRQ]), (2) maximum drinks...
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