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Article

The Relationship between Gene-Specific DNA Methylation in Leukocytes and Normal Colorectal Mucosa in Subjects with and without Colorectal Tumors

1 Mar 2009

Abstract excerpt

CpG island methylation in the promoter regions of tumor suppressor genes has been shown to occur in normal colonic tissue and can distinguish between subjects with and without colorectal neoplasms. It is unclear whether this relationship exists in other tissues such as blood. We report the relationship between estrogen receptor gene (estrogen receptor alpha) methylation in leukocyte and normal colonic tissue DNA...

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Share to Cancer-related gene regulation
Share to Epigenetics and DNA Methylation
Share to Genetic factors in colorectal cancer

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PMID: 19258481
DOI: 10.1158/1055-9965.epi-08-0703

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