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Article

Defining Protective Responses to Pathogens: Cytokine Profiles in Leprosy Lesions

11 Oct 1991

Abstract excerpt

The immunological mechanisms required to engender resistance have been defined in few infectious diseases of man, and the role of specific cytokines is unclear. Leprosy presents clinically as a spectrum in which resistance correlates with cell-mediated immunity to the pathogen. To assess in situ cytokine patterns, messenger RNA extracted from leprosy skin biopsy specimens was amplified by the polymerase chain...

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Identifiers

PMID: 1925582
DOI: 10.1126/science.1925582

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