Article
Immune regulation: learning from leprosy.
Hospital practice (Office ed.) - 15 Nov 1993
Modlin R L, Bloom B R
Abstract excerpt
The specific anergy seen in severe, disseminated leprosy appears to represent multifaceted actions of macrophages and suppressor T lymphocytes. Identification of cytokine mediation in these events helps to account for the immune system's "choice" of cellular versus humoral defenses--and points toward manipulation of cytokine switches for immunotherapy against infectious and autoimmune disease.
Topics
- Cytokines
- Humans
- Immunity, Cellular
- Leprosy, Lepromatous
- Leprosy, Tuberculoid
- Mycobacterium leprae
- Phenotype
- T-Lymphocytes