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Article

In vivo cytokine profiles in patients with kala-azar. Marked elevation of both interleukin-10 and interferon-gamma.

The Journal of clinical investigation - 1 Apr 1993

Karp C L, el-Safi S H, Wynn T A, Satti M M, Kordofani A M, Hashim F A, Hag-Ali M, Neva F A, Nutman T B, Sacks D L

Abstract excerpt

The immunological mechanisms underlying the susceptibility to disseminated visceral parasitism of mononuclear phagocytes in patients with kala-azar remain undefined. Resistance and susceptibility are correlated with distinct patterns of cytokine production in murine models of disseminated leishmanial disease. To assess lesional cytokine profiles in patients with kala-azar, bone marrow aspirates were analyzed...

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Identifiers

PMID: 8097208
DOI: 10.1172/JCI116372
PMCID: PMC288142

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