Article
In vivo cytokine profiles in patients with kala-azar. Marked elevation of both interleukin-10 and interferon-gamma.
The Journal of clinical investigation - 1 Apr 1993
Karp C L, el-Safi S H, Wynn T A, Satti M M, Kordofani A M, Hashim F A, Hag-Ali M, Neva F A, Nutman T B, Sacks D L
Abstract excerpt
The immunological mechanisms underlying the susceptibility to disseminated visceral parasitism of mononuclear phagocytes in patients with kala-azar remain undefined. Resistance and susceptibility are correlated with distinct patterns of cytokine production in murine models of disseminated leishma...
Topics
- Adolescent
- Adult
- Base Sequence
- Bone Marrow
- CD4-Positive T-Lymphocytes
- Child
- Cytokines
- Female
- Humans
- Interferon-gamma
- Interleukin-10
- Leishmaniasis, Visceral
- Male
- Middle Aged
- Molecular Sequence Data