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Article

Effective detection of human leukocyte antigen risk alleles in celiac disease using tag single nucleotide polymorphisms.

PloS one - 28 May 2008

Monsuur Alienke J, de Bakker Paul I W, Zhernakova Alexandra, Pinto Dalila, Verduijn Willem, Romanos Jihane, Auricchio Renata, Lopez Ana, van Heel David A, Crusius J Bart A, Wijmenga Cisca

Abstract excerpt

BACKGROUND: The HLA genes, located in the MHC region on chromosome 6p21.3, play an important role in many autoimmune disorders, such as celiac disease (CD), type 1 diabetes (T1D), rheumatoid arthritis, multiple sclerosis, psoriasis and others. Known HLA variants that confer risk to CD, for example, include DQA1*05/DQB1*02 (DQ2.5) and DQA1*03/DQB1*0302 (DQ8). To diagnose the majority of CD patients and to study...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 18509540
DOI: 10.1371/journal.pone.0002270
PMCID: PMC2386975

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