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Article

Combined effects of MC4R and FTO common genetic variants on obesity in European general populations.

Journal of molecular medicine (Berlin, Germany) - 1 May 2009

Cauchi Stéphane, Stutzmann Fanny, Cavalcanti-Proença Christine, Durand Emmanuelle, Pouta Anneli, Hartikainen Anna-Liisa, Marre Michel, Vol Sylviane, Tammelin Tuija, Laitinen Jaana, Gonzalez-Izquierdo Arturo, Blakemore Alexandra I F, Elliott Paul, Meyre David, Balkau Beverley, Järvelin Marjo-Riitta, Froguel Philippe

Abstract excerpt

Genome-wide association scans recently identified common polymorphisms, in intron 1 of FTO and 188 kb downstream MC4R, that modulate body mass index (BMI) and associate with increased risk of obesity. Although their individual contribution to obesity phenotype is modest, their combined effects an...

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Source

Identifiers

PMID: 19255736
DOI: 10.1007/s00109-009-0451-6

Genes

FTO

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19255736-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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