Article
Sequence variations in the public human genome data reflect a bottlenecked population history.
Proceedings of the National Academy of Sciences of the United States of America - 7 Jan 2003
Marth Gabor, Schuler Greg, Yeh Raymond, Davenport Ruth, Agarwala Richa, Church Deanna, Wheelan Sarah, Baker Jonathan, Ward Ming, Kholodov Michael, Phan Lon, Czabarka Eva, Murvai Janos, Cutler David, Wooding Stephen, Rogers Alan, Chakravarti Aravinda, Harpending Henry C, Kwok Pui-Yan, Sherry Stephen T
Abstract excerpt
Single-nucleotide polymorphisms (SNPs) constitute the great majority of variations in the human genome, and as heritable variable landmarks they are useful markers for disease mapping and resolving population structure. Redundant coverage in overlaps of large-insert genomic clones, sequenced as part of the Human Genome Project, comprises a quarter of the genome, and it is representative in terms of base...
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